Home FleetWatch 2015 Become a bone marrow stem cell donor

Become a bone marrow stem cell donor


Although not strictly related to trucking, FleetWatch brings this story to you in the hope of encouraging as many people as possible to consider becoming a potential bone marrow stem cell donors.

Every year thousands of people are diagnosed with leukemia and for most, the only hope of recovery is to undergo a bone marrow stem cell transplant. The search for a donor can be very challenging and this is where help is needed.

As a part of the Bone Marrow and Leukaemia Awareness Campaign which runs from 15th August until 15th  October ER24 and the South African Bone Marrow Registry (SABMR), are urging the public to consider becoming possible donors – the more different people on the register the higher the chance of a successful match.

Professor Ernette du Toit, medical director and co-founder of the SABMR, said, “Leukaemia, cancer of the white cells, knows no limits and affects people of all ages and ethnicities. Sadly, it is the most common form of childhood cancer. Donors are a key component to saving lives, and that begins with you,” she said.

Leukaemia patients are not the only ones in need of stem cell transplants. People with illnesses such as non-Hodgkin lymphoma (cancer of lymphatic system), bone marrow failure (severe aplastic anaemia) and some genetic blood and immune system disorders such as sickle cell anaemia also require bone marrow stem cell transplants.

“These illnesses can affect anyone. Although bone marrow transplants are not always successful, they often give someone their only chance of recovery. The SABMR’s youngest patient was an infant just 10 months old,” said Prof Du Toit.

At present there are 70 000 donors on the SABMR. While it may seem like a lot, more donors are needed considering that a perfect match is required.

Support National Bandana DayProf Du Toit added that there is a very large number of possible tissue types. The best chance of finding a match is within the patient’s family. “There is a 25 percent chance of finding a matching sibling donor but with smaller family sizes and more diverse families, these odds are dropping. For the majority of patients, they will need to find a matching unrelated donor. This is where the SABMR comes in. We are the only medical facility in South Africa that conducts complex searches to identify life-saving donors,” said Prof Du Toit. The chance of finding a matched unrelated donor is just 1 in 100 000. “This is the average. For some with more common tissue types, chances may be better. Sadly, for some other patients, chances are much less,” she said.

She added that it is more likely to find a matching donor for a patient from the same ethnic group.

Greater challenge for some ethnic graps

This is however a greater challenge in some ethnic groups than in others. For example, there are only 4 500 potential donors on the registry who are black according to Prof Du Toit. She said this is a concern considering the population distribution in South Africa. “While it is possible to find a matching donor from a different ethnic group to the patient, it is less likely. It is just a matter of frequency,” she said.

The SABMR often searches for perfectly matched donors worldwide.

“Donors living in other countries are found for 75 percent of patients in South Africa. This is made possible through the SABMR’s collaboration with 67 registries worldwide, with 27 million registered donors. Our staff has travelled as far as Taiwan to collect these cells. This is somewhat of a ‘military operation’ to ensure that the cells reach our patients within 72 hours. While our staff collect the donated cells, our patients have their diseased bone marrow cells destroyed with chemotherapy. This leaves a window period of 72 hours during which the patient must receive the matched healthy cells,” said Prof Du Toit.

The SABMR has also identified several South African donors that have matched overseas patients.

Fear of becoming donors

Many people fear signing up as potential donors because they believe the procedure to retrieve the stem cells involves a large needle being inserted into their bones.

This is not the case. Stem cells are collected from the donor’s blood, in a similar way that one would donate blood or platelets. Prof Du Toit said most donors describe the process as uncomfortable but not painful. If you are on the registry and turn out to be a possible match, the following will happen:

  • You will receive a call from the SABMR informing you that you have been identified as a potential match for a patient. If you are willing to proceed, the SABMR will arrange for you to undergo several additional blood tests to further establish the suitability of your bone marrow.
  • Once confirmed as a match, you will undergo a health check-up by a medical doctor.
  • You will receive daily injections of neupogen from a week prior to the procedure. Neupogen is a naturally occurring hormone in the body that stimulates the production of stem cells. The injections ensure the donor produces sufficient cells for their body and for the patient. Some donors experience flu-like symptoms which is a side effect of the neupogen.
  • On the day of the procedure, the donor will be admitted to a collection facility and attached to a cell-separator machine, usually by intravenous line in both arms. It usually takes four to six hours to collect the stem cells. An SABMR member will accompany the donor throughout the process.
  • On completion, the SABMR member will ensure the cells are transported safely to the patient


So where do you start if you would like to become a potential donor? All healthy individuals aged 18 to 45 can register as a potential donor by contacting the Sunflower Fund, the SABMR recruiting agency, on 0800 121 082. If you fulfil the criteria you will receive an application form and health questionnaire. You will be directed to a blood sampling facility to determine your tissue type.

Your form and tissue typing result will be forwarded to the SABMR, where your details will be entered into the SABMR database. You will receive an SABMR donor card to confirm that you are a potential donor. You will remain on the SABMR database until your 60th birthday, or until you ask to be removed. If you have concerns about becoming a donor, e-mail: admin@sabmr.co.za

Visit www.sabmr.co.za for further information. ER24’s Emergency Contact Centre can be reached 24 hours a day on 084 124 for any medical emergency.

Related Images:


Please enter your comment!
Please enter your name here